Is 4000 D-dimer high?

Is 4000 D-dimer high?

Conclusion: D-dimer value more than 4000 ng/ml had high positive prediction value (79%) in suspected clinical cases. Value more than 8000 ng/ml further improve value to nearly 100% in suspected cases.

What is considered an extremely high D-dimer level?

Very high D-dimer level was defined as 100 times above the cutoff point, i.e. equal to or greater than 50 mg/L FEU. We analyzed the results of the 1,053 samples, reviewed the history of the patients with very high D-dimer through the hospital computer system, and found out the causes producing very high D-dimer.

What causes D-dimer elevation?

Additionally, D-dimer levels may be elevated in the setting of pregnancy, inflammation, malignancy, trauma, postsurgical treatment, liver disease (decreased clearance), and heart disease. It is also frequently high in hospitalized patients.

How high is D-dimer in PE?

Our center defines high D-dimer levels as >1.3 µg/ml, but the ROC curve analysis suggested that 1.9 µg/ml was the optimal threshold for the diagnosis of PE in our patient sample.

Can high D-dimer mean nothing?

An elevated D-dimer level is not normal. It’s usually found after a clot has formed and is in the process of breaking down. If you are having significant formation and breakdown of blood clot in your body, your D-dimer may be elevated. A negative D-dimer test means that a blood clot is highly unlikely.

What cancers cause high D-dimer?

The plasma levels of D-dimer were significantly higher in patients with breast cancer (P=0.0022), gastric cancer (P<0.0001), pancreatic cancer (P=0.0003), colon cancer (P=0.0001) and rectal cancer (P=0.0028), compared with the healthy controls.

Is an elevated D-dimer an emergency?

Background: Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them.

What is D-dimer range?

D-dimer is the degradation product of crosslinked (by factor XIII) fibrin. It reflects ongoing activation of the hemostatic system. The reference concentration of D-dimer is < 250 ng/mL, or < 0.4 mcg/mL.

What is best D-dimer value?

In the first study (PE confirmed patients/study population = 134/370), it was reported that the best D-dimer cutoff level for significant PE risk = should be 2.152 mg/L (AUC, 0.69; 95% CI, 0.64–0.74; p < 0.05) [11].

IS 700 D-dimer high?

The reference range can vary from laboratory to laboratory, but in general, a normal D-dimer range is 220 to 500 ng/mL. 16 If your results come back normal or low, then it is unlikely you have a blood clot. High or abnormal results suggest you may have a blood clot, but it does not definitively mean a clot is present.

What cancers cause a high D-dimer?

What is considered a critical D-dimer?

What is the D-dimer test and how does it work?

Articles On What Is the D-Dimer Test? A D-dimer test is a blood test that can be used to help rule out the presence of a serious blood clot. When you get a cut, your body takes a bunch of steps to make your blood clump up.

What is the normal range for D-dimer in blood?

The normal amounts for D-dimer in the blood should be around 0.5 mg/l of blood or 500 ng/ml of blood.

Can a positive D-dimer test predict a blood clot?

However, a positive D-dimer test cannot predict whether or not a blood clot is present. However, a positive D-dimer test does not tell your doctor where the blood clot was or what caused it. Other health problems can also cause the D-dimer level to go up (see High D-dimer levels below for causes). Therefore, the D-dimer test is not

What causes high D dimer levels in blood?

Also, high D-Dimer levels are not always caused by clotting problems. Other conditions that can cause high D-Dimer levels include pregnancy, heart disease, and recent surgery. If your D-Dimer results were not normal, your provider will probably order more tests to make a diagnosis.